Polynucleotide Skin Tightening

Polynucleotides are natural DNA fragments that trigger skin repair and regeneration, improving elasticity, hydration, and fine lines.

‍

Injected into the dermis, polynucleotides stimulate fibroblast activity, improve tissue elasticity, and enhance microcirculation.

‍

Face, neck, décolletage, under-eyes and scalp (for hair loss).

Gradual improvement from 2–3 weeks, with optimal tightening at 6–8 weeks.

‍

Most patients tolerate it well. A topical anaesthetic is used for comfort.

Up to 12 months after a full course.

Approximately 30–45 minutes.

Temporary redness, mild swelling, or bruising can occur. Allergic reactions are extremely rare.

A course of 2–3 sessions spaced 3–4 weeks apart is recommended.

Croma’s polynucleotides are derived from freshwater fish, which is halal.

• The product is highly purified DNA fragments — no fish protein, flesh, or cells remain.
• There are no shellfish components (important for allergy and some halal concerns)
• Most scholars consider fish-derived biotechnology products to be halal, especially when purified. Polynucleotides are therefore generally acceptable.

Polynucleotides and Botox are both excellent treatments — but they do completely different things.

The right choice depends on what you’re trying to improve.

Botox: Best for Movement Lines

Botox works by relaxing overactive muscles, which softens lines caused by expressions, such as:

• Frown lines (11s)
• Forehead lines
• Crow’s feet
• Bunny lines
• Gummy smile

Botox is ideal if your main concern is:

• Wrinkles that appear when you move your face
• Deep lines forming from frowning or squinting
• Wanting a smoother, more refreshed look
• Preventing lines from getting deeper over time

Botox does not treat: skin quality, pigmentation, dark circles, or texture.

Polynucleotides: Best for Skin Quality

Polynucleotides are bio-stimulators that repair, hydrate, and regenerate the skin.

They improve:

• Fine lines
• Skin texture
• Under-eye crepiness
• Dullness
• Elasticity
• Early ageing and dehydration lines

They work beautifully in areas where Botox is either unsuitable or less effective, especially:

• Under-eyes
• Neck
• Crepey skin
• Acne-prone or dehydrated skin

Polynucleotides do not stop muscle movement, so they won’t soften expression lines the way Botox does.

Which One Is Better?

Neither is “better” — they treat different concerns.

• Choose Botox if your goal is smoother skin by reducing muscle movement.
• Choose Polynucleotides if your goal is healthier, brighter, more hydrated skin.

Most clients actually benefit from a combination for a natural, refreshed result.

The Best Approach? A Personalised Plan

At Harley Street MD, we assess:

• Your skin
• Your concerns
• Your anatomy
• Your goals

Then we recommend the treatment (or combination) that will give you the most natural and effective outcome.

Polynucleotides are very safe and well-tolerated, but like any injectable treatment, there are a few things to be aware of.

1. Multiple Sessions Are Needed

Polynucleotides usually require 2–3 sessions (sometimes 4 for under-eyes), spaced 2–3 weeks apart. Results build gradually, rather than appearing instantly.

2. Subtle, Not Dramatic Results

They improve:

• Hydration
• Fine lines
• Crepiness
• Skin texture
• Under-eye quality

However, they do not add volume and cannot erase deep wrinkles. Clients seeking a dramatic change may benefit from combining them with filler or Botox.

3. Temporary Bumps After Treatment

Because the product is injected superficially, you may notice small bumps or “bee-sting” marks, especially under the eyes. These typically settle within 12–48 hours.

4. Mild Injection Side Effects

Common, short-term effects include:

• Redness
• Bruising
• Swelling
• Tenderness

These usually resolve quickly.

5. Results Are Not Permanent

Results typically last 6–9 months, depending on:

• Skin type
• Severity of concerns
• Lifestyle
• Treatment area

Maintenance sessions are recommended to sustain results, typically 1 session every 6 months.

6. Not a Substitute for Botox or Filler

Polynucleotides do not treat:

• Strong expression lines
• Deep wrinkles
• Significant volume loss
• Sagging

They work best as part of a combined approach for a refreshed, natural look.

Overall Safety Profile

Polynucleotides have one of the best safety profiles in aesthetics. They are:

• Non-toxic
• Anti-inflammatory
• Biocompatible
• Suitable for sensitive or delicate areas like the under-eye

Serious complications are extremely rare.

Do’s and Don’ts After Polynucleotide Treatments

Following these recommendations helps you get the best results and minimise side effects.

Do’s

• Keep the area clean: Gently cleanse your face without rubbing.
• Stay hydrated: Drinking water supports skin health and recovery.
• Protect from sun: Use SPF 30+ to prevent pigmentation and protect healing skin.
• Follow your treatment schedule: Attend all recommended sessions for optimal results.
• Sleep on your back: Avoid pressing your face into pillows for the first night if possible.
• Contact your clinician if needed: Reach out if you notice unusual swelling, redness, or discomfort.

Don’ts

• Do not rub or massage the treated area: This can move the product or irritate skin.
• Avoid heavy exercise for 24–48 hours: Sweating may increase bruising or swelling.
• No alcohol for 24 hours: Alcohol can exacerbate swelling or bruising.
• Avoid extreme heat or cold: Saunas, hot baths, or ice packs can affect results.
• Do not have facial treatments immediately: Avoid facials, chemical peels, or laser treatments for at least a week unless advised.
• Do not self-inject or use other products in the area: Only a trained practitioner should treat the area during the recovery period.